Keith M. Davies

RESEARCH PUBLICATIONS          

HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH. Salmon, Debra; Torres de Holding, Claudia; Thomas, Lynta; Peterson, Kyle; Goodman, Gens; Saavedra, Joseph; Srinivasan, Aloka; Davies, Keith; Keefer, Larry; Miranda, Katrina. Inorganic Chemistry. 2011, 50 (8), pp 3262–3270

Reactivity of O2-arylated diazeniumdiolate prodrugs in aqueous and phospholipid liposome media. Matthew S. Ning,  Ramtin Ghods  and Keith M. Davies. Journal of  Undergraduate Chemistry Research, 2010, 9(4), 97-101.

Nucleophilic reactivity of thiolate, hydroxide and phenolate ions towards a model O2-arylated diazeniumdiolate prodrug in aqueous and cationic surfactant media.  Matthew S. Ning, Stacy E. Price, Jackie Ta and Keith M. Davies, Journal of Physical Organic Chemistry, 2010, 23, 220-226.

Unexpected Incorporation of Bromide at a Non-Anomeric Position during Synthesis of an O2-Glycosylated Diazeniumdiolate, Joseph E. Saavedra,  Keith M. Davies, Joseph J. Barchi, Jr., and Larry K. Keefer, Organic Preparations and Procedures International 2009, 41, 141-145.

Thiol activation of a model O2-aryl diazeniumdiolate prodrug in phospholipid vesicle media. Bach T. Dinh, Mohamad N. Zanbrakji, Kevin Dove, Stacy E. Price, Marit Peterson, Keith M. Davies,  NITRIC OXIDE: Biology and Chemistry, 2008, 19, 326-332.

Hydrolytic Reactivity Trends among Potential Prodrugs of the O2-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity. Carlos A. Valdez, Joseph E. Saavedra, Brett M. Showalter, Keith M. Davies,  Thomas C. Wilde, Michael L. Citro, Joseph J. Barchi, Jr., Jeffrey R. Deschamps, Damon Parrish, Stefan El-Gayar, Ulrike Schleicher,  Christian Bogdan, Larry K. Keefer, Journal of Medicinal Chemistry, 2008, 51, 3961-3970.

Diazeniumdiolate reactivity in model membrane systems. Bach T. Dinh, Stacy E. Price, Amr Majul, Mazen El-Hajj, Victor Morozov, Joseph A. Hrabie, Keith M. Davies. Nitric Oxide, Biology and Chemistry, 2008, 18, 113-121. 

PABA/NO as an Anticancer Lead: Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity toward Glutathione, and in Vitro Activity. Saavedra, J. E.; Srinivasan, A.; Buzard, G. S.; Davies, K. M.; Waterhouse, D. J.; Inami, K.; Wilde, T. C.; Citro, M. L.; Cuellar, M.; Deschamps, J. R.; Parrish, D.; Shami, P. J.; Findlay, V. J.; Townsend, D. M.; Tew, K. D.; Singh, S.; Jia, L.; Ji, X.; Keefer, L. K. Journal of Medicinal Chemistry, 2006, 49, 1157-1164.                  

Injectable Formulation of Disodium 1-[2-(Carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an Ultrafast Nitric Oxide Donor Prodrug. David J. Waterhouse, Joseph E. Saavedra, Keith M. Davies, Michael L. Citro, Xia Xu, Douglas A. Powell, George J. Grimes, Gopal K. Potti, and Larry K. Keefer, Journal of Pharmaceutical Sciences, 2006, 95(1), 108-115.

Effect of Hydrophobic Structure on the Catalysis of Nitric Oxide Release from Zwitterionic Diazeniumdiolates in Surfactant and Liposome Media. Bach T. Dinh, Kevin Dove, Dilara Jappar,  Joseph A. Hrabie and Keith M. Davies. Nitric Oxide: Biology and Chemistry. 2005, 13, 204-209.

Diazeniumdiolate Ions as Leaving Groups in Anomeric Displacement Reactions: A Protection-Deprotection Strategy for Ionic Diazeniumdiolates. Brett M. Showalter, Melissa M. Reynolds, Carlos A. Valdez,  Joseph E. Saavedra, Keith M. Davies,| John R. Klose, Gwendolyn N. Chmurny, Michael L. Citro,  Joseph J. Barchi, Jr.,  Scott I. Merz, Mark E. Meyerhoff  and Larry K. Keefer. Journal of the American Chemical Society, 2005, 127, 14188-14189.

Chemistry of the Diazeniumdiolates: Z  E Isomerism. Wang, Y.-N.; Bohle, D. S.; Bonifant, C. L.; Chmurny, G. N.; Collins, J. R.; Davies, K. M.; Deschamps, J.; Flippen-Anderson, J. L.; Keefer, L. K.; Klose, J. R.; Saavedra, J. E.; Waterhouse, D. J.; Ivanic, J. Journal of the American Chemical Society, 2005; 127(15); 5388-5395. 

JS-K, a Glutathione/Glutathione S-Transferase-Activated Nitric Oxide Donor of the Diazeniumdiolate Class with Potent Antineoplastic Activity. Paul J. Shami, Joseph E. Saavedra, Lai Y. Wang, Challice L. Bonifant, Bhalchandra A. Diwan, Shivendra V. Singh, Yijun Gu, Stephen D. Fox, Gregory Buzard, Michael L. Citro, David J. Waterhouse, Keith M. Davies, Xinhua and Larry K. Keefer. Molecular Cancer Therapeutics, 2003, 2, 409-417. 

Micellar Catalysis of Nitric Oxide Dissociation from Diazeniumdiolates. Stacy E. Price, Dilara Jappar, Patricia Lorenzo, Joseph A. Hrabie, Joseph E. Saavedra and Keith M. Davies. Langmuir, 2003, 19,2096-2102. 

Preparation and Reactivity of  O2-Sulfonated Diazeniumdiolates. Raechelle A. D’Sa, Yuhong Wang, Patrick H. Ruane, Brett M. Showalter, Joseph E. Saavadra, Keith M. Davies, Michael L. Citro, Melissa N. Booth, Larry K. Keefer and John P. Toscano. Journal of Organic Chemistry, 2003, 68, 656-657. 

Mechanistic Insight into Exclusive Nitric Oxide recovery from a Carbon-Bound Diazeniumdiolate. Ernst V. Arnold, Michael L. Citro, Evelyn A. Saavedra, Keith M. Davies, Larry K. Keefer and Joseph A. Hrabie. NITRIC OXIDE: Biology and Chemistry, 2002, 7, 103-108.  

Chemistry of Diazeniumdiolates. 2. Kinetics and Mechanisms of Dissociation to Nitric Oxide in Aqueous Solution. Keith M. Davies, David A. Wink, Joseph E. Saavedra and Larry K. Keefer. Journal of the American Chemical Society, 2001, 123, 5473-5481. 

Chemistry of the Diazeniumdiolates. 3. Photoreactivity. Aloka Srinivasan, Joseph E. Saavedra, Naod Kebede, Alexander V. Nikolaitchik, Daniel A. Brady, Emily Yourd, Keith M. Davies, John P. Toscana and Larry K. Keefer. Journal of the American Chemical Society, 2001, 123, 5465-5472. 

The Secondary Amine/Nitric Oxide Complex Ion R2N[N(O)NO]- Ion as Nucleophile and Leaving Group in SNAr Reactions. Joseph E. Saavedra, Aloka Srinivasan, Challice L. Bonifant, Jingxi Chu, Anna P. Shanklin, Judith L. Flippen-Anderson, William G. Rice, Jim A. Turpin, Keith M. Davies, and Larry K. Keefer. Journal of Organic Chemistry, 2001, 66, 3090-3098. 

Esterase-Sensitive Nitric Oxide Donors of the Diazeniumdiolate Family. In Vitro Antileukemic Activity. Joseph E. Saavedra, Paul Shami, Lai Yi Wang, Keith M. Davies, Melissa N. Booth, Michael L. Citro and Larry K. Keefer. Journal of Medicinal Chemistry, 2000, 43, 261-269. 

Conversion of a Polysaccharide to Nitric Oxide-Releasing Form. Dual-Mechanism Anticoagulant Activity of Diazeniumdiolated Heparin. Joseph E. Saavedra, Daniel L. Mooradian, Kelly A. Mowery, Mark H. Schoenfisch, Michael L. Citro, Keith M. Davies, Mark E. Meyerhoff, Larry K. Keefer. Bioorganic & Medicinal Chemistry Letters. 2000, 10, 751-753. 

Piperazine as a Linker for Incorporating the Nitric Oxide-releasing Diazeniumdiolate Group into Other Biomedically Relevant Functional Molecules. Joseph E. Saavedra, Melissa N. Booth, Joseph A. Hrabie, Keith M. Davies, Larry K. Keefer. Journal of Organic Chemistry 1999, 64, 5124-5139.  

Adducts of Piperazine with Nitric Oxide. Joseph A. Hrabie, Joseph E. Saavedra, J. Keith M.  Davies, K. M,. Larry K. Keefer. Org. Prep. Proceed. Int. 1999, 31, 189-192.

Electrochemical Investigation of Amphiphilic Cobalt(III) Complexes and Ferrocene Derivatives in SDS Microemulsions. Keith M. Davies, Dilip M. Shah and Abul Hussam.  Langmuir, 1997, 13, 4729. 

Boundary Layer Infusion of Nitric Oxide Reduces Early Smooth Muscle Cell Proliferation in the Endarterectomized Canine Artert. Changyi Chen, Stephen R. Hanson, Larry K. Keefer, Joseph E. Saavedra, Keith M. Davies, Thomas C. Hutsell, John D. Hughes, David N. Ku, and Alan B. Lumsden. Journal of Surgical Research, 1997, 67, 26. 

Localizing Antithrombotic and Vasodilatory Activity with a Novel, Ultrafast Nitric Oxide Donor. Joseph E. Saavedra, Garry D. Southan, Keith M. Davies, Anders Lundell, Chris Markou, Stephen R. Hanson, Christophe Adrie, William E. Hurford, Warren M. Zapol, and Larry K. Keefer. Journal of Medicinal Chemistry, 1996, 39, 4361- 4365. 

"NONOates" (1-Substituted Diazen-1-ium-1,2-diolates) as NO Donors: Convenient Nitric Oxide Dosage Forms. Larry K. Keefer, Raymond W. Nims, Keith M. Davies and David A. Wink. Methods in Enzymology, 1996, 268, 281. 

Nitric Oxide-Releasing Polymers Containing the [N(O)NO]- Group. Daniel J. Smith, Debashish Chakravarthy, Sharon Pulfer, Maia L. Simmons, Joseph A. Hrabie, Michael L. Citro, Joseph E. Saavedra, Keith M. Davies, Thomas C. Hutsell, Daniel L. Mooradian, Stephen R. Hanson and Larry K. Keefer. Journal of Medicinal Chemistry, 1996, 39, 1148. 

A Simple Method for the Determination of the Temperature Coefficient of Voltaic Cell Voltage: An Application in Exploring the Gibbs-Helmholtz Equation. Alfred E. Saieed and Keith M. Davies.  Journal of Chemical Education, 1996, 73, 959. 

Redox Reactions of Lipophilic Metal Complexes in Aqueous Surfactant Media. Correlation of Rate and Electrochemical Behavior. Keith M. Davies, Abul Hussam, Bayne R. Rector, Iris Owen and Peter King. Inorganic Chemistry, 1994, 33, 1741. 

Electrochemical Studies of Metal Complexes in Sodium Dodecyl Sulfate Micellar Solution. Keith M. Davies and Abul Hussam, Langmuir, 1993, 9, 3270. 

Effect of Solvent on the Stability and Electron Transfer Kinetics of 1,8‑Bis(2‑Pyridyl)‑3,6‑dithiaoctane Copper(II).  Keith M. Davies, Kendall D. Whyte, John Liebermann and Jennifer A. Mahr, Polyhedron, 1991, 10, 1647. 

Electrolyte Effects in Electron Transfer Reactions of 1,8‑Bis(2‑pyridyl)‑3,6‑dithiaoctane Copper(II) with Ferrocene in Acetonitrile. Specific Rate Enhancement by Tetrafluoroborate Ion.  Keith M. Davies, Kendall D. Whyte and Arthur H. Gilbert, Inorganica Chimica Acta, 1990, 177, 121. 

Redox Behavior of Copper(II) and Copper(I) Complexes with Tetradentate Bis(pyridyl)‑dithiaether and Bis(pyridyl)‑diaza Ligands towards Ruthenium Ammine and Bipyridyl Complexes.  Keith M. Davies and Bardia Guilani, Inorganica Chimica Acta, 1987, 127, 223. 

Kinetic Studies of Electron Transfer Reactions of Sterically Constrained Bis(Diimine) Complexes of Copper(II) and Copper(I) with Ruthenium Ammine Complexes.  Keith M. Davies and Brien Byers, Inorganic Chemistry, 1987, 26, 3823. 

Electron Transfer Reactions of Copper(I) and (2,9‑Dimethyl‑1,10‑phenanthroline) Copper(II) with some Ammine Complexes of Ruthenium(III) and (II), Keith M. Davies, Inorganic Chemistry,  1983, 22, 615.  

A Linear Free Energy Relationship for Outer‑Sphere Reduction of Ru(III) Ammine Complexes by Ti(III), Keith M. Davies and Joseph E. Earley, Inorganic Chemistry, 1978, 17, 3350. 

Thiocyanate Ion as a Bridging Ligand for Electron‑Transfer Between Ruthenium(III) and Titanium(III), Joseph E. Earley, Ruth A. Lee and Keith M. Davies, Proceedings of XIX International Conference on Coordination Chemistry, Prague, Czechoslovakia, July, 1978

Kinetics of Reduction of Ru(NH3)63+ and Ru(NH3)5Cl2+ by Ti(III), Purushothaman Chalilpoyil, Keith M. Davies and Joseph E. Earley, Inorganic Chemistry, 1977, 16, 3344.

Linear Free Energy Relationship for Some Inner‑Sphere Electron‑Transfer Reactions, Keith M. Davies and Joseph E. Earley, Inorganic Chemistry, 1976, 15, 1074. 

The Reaction Between Ferricyanide and Nitric and Nitrous Acids, Part II.  The Structure of the Intermediate Species, J. C. Bates, Keith M. Davies and Geoffrey Stedman, Journal of the Chemical Society, Dalton Transactions, 1974, 2182‑2186. 

The Kinetics of the Reaction of Ferricyanide Ion with Nitric and Nitrous Acids, Keith M. Davies and Geoffrey Stedman.  Journal of the Chemical Society, Dalton Transactions, 1974, 2276‑2181. 

Redox Equilibria Between Ferricyanide, Ferrocyanide, and Nitric and Nitrous Acids, J. C. Bates, Keith M. Davies and Geoffrey Stedman, Journal of the Chemical Society, Dalton Transactions, 1974, 246‑248. 

The Kinetics of the Reduction of the m‑Amido‑m‑Superoxo‑ Complexes (bipy)2Co.m(NH2,O2).Co(bipy)24+ and (phen)2Co.m(NH2,O2).Co(phen)24+ with Iron(II) and Related Studies, Keith M. Davies and A. Geoffrey Sykes, Journal of the Chemical Society, 1971, 1414‑1417. 

Factors Affecting Electron Transfer Reactions Between O2 and O22‑ Bridging Ligands in Binuclear Complexes of Cobalt(III), Keith M. Davies and A. Geoffrey Sykes, Journal of the Chemical Society, 1971, 1418‑1423. 

A Kinetic Study of the First Step of the Oxidation of Vanadium(IV) by Chromium(VI), Keith M. Davies and James H. Espenson, Journal of the American Chemical Society, 1970, 92, 1889‑1892. 

Kinetics and Mechanism of the Oxidation of Vanadium(III) by Chromium(VI) in Aqueous Perchloric Acid Solutions, Keith M. Davies and James H. Espenson, Journal of the American Chemical Society, 1970, 92, 1884‑1888. 

The cobalt(II) Intermediate in the Reactions of Vanadium(II) and Monosubstituted Pentacyanocobaltate(III) Ions, Keith M. Davies and James H. Espenson, Chemical Communications, 1970, 111. 

Electron‑Transfer Reactions of Vanadium(II) and some Monosubstituted Pentacyanocobaltate(III) Ions, Keith M. Davies and James H. Espenson, Journal of the American Chemical Society,  1969, 91, 3093‑3094.

Reaction of Nitrogen Dioxide with Ferricyanide, Keith M. Davies and Geoffrey Stedman, Chemical Communications, 1968, 118‑119.

 

Research Presentations:

Reactivity of thiolate, hydroxide, and phenolate ions toward O2-arylated diazeniumdiolate prodrugs. Matthew S. Ning, Ramtin Ghods, Jackie Ta and  Keith M. Davies, Fall-2009 ACS National Meeting, Washington D.C., August 13, 2009.

Thiol activation of O2-arylated diazeniumdiolate prodrugs. Jackie Ta and Keith M. Davies, 7th Annual Undergraduate Research Conference, Georgetown University, April 3, 2009.

O2-Glycosylated diazeniumdiolates: Targeting nitric oxide to macrophages for antileishmanial activity. Larry K. Keefer, Carlos A. Valdez, Joseph E. Saavedra, Brett M. Showalter, Keith M. Davies, Thomas C. Wilde, Michael L. Citro, Joseph J Barchi Jr., Jeffrey R. Deschamps, Damon A. Parrish, Stefan El-Gayar, Ulrike Schleicher, and Christian Bogdan. 236th ACS National Meeting, MEDI 452, Philadelphia, PA, August 17-21, 2008.  

Diazeniumdiolate prodrug activation in model membrane systems. Keith M. Davies, Bach T. Dinh and Kevin, J. Dove, 232nd ACS National Meeting, INORG 138, San Francisco, CA, September 10, 2006.  

Model Membrane Systems and Nitric Oxide Dissociation from Diazeniumdiolate Ions. Keith M. Davies, Invited Seminar, Howard University, Washington, D.C. March, 2006. 

Effect of model membrane systems on nitric oxide dissociation from diazeniumdiolate ions. Keith M. Davies, Bach T. Dinh, Kevin, J. Dove and Mazen El-Hajj,  230th  ACS National Meeting, BIOL 96, Washington D.C., Aug 30th, 2005.

Diazeniumdiolate Reactivity in Anionic Liposome Media. Mazen El-Hajj, Bach Dinh and Keith M. Davies. Colonial Academic Alliance Undergraduate Research Conference, Hofstra, N.Y., April 8-9, 2005

Liposome Transport and Reactivity of Diazeniumdiolates, Bach Dinh and Kevin Dove, Virginia Academy of Science, Undergraduate Research Symposium, Richmond, Virginia, October 2004. 

Diazeniumdiolate Reactivity in Liposome Media. Marit C. Barnett, Kevin J. Dove, Keith M. Davies. CHED 165. 228th ACS National Meeting, Philadelphia, PA, August 22-26, 2004.  

Chemistry of the Diazeniumdiolates. RHN[N(O)NO]- Ions as Progenitors of Both Nitroxyl and Nitric Oxide. Aloka Srinivasan, Michael L. Citro, Keith M. Davies, Michael G. Espey, Larry K. Keefer, Katrina M. Miranda, Lisa A. Ridnour, Joseph E. Saavedra, Lynta Thomas, Douglas D. Thomas, David J. Waterhouse and David A. Wink. TOXI 0054. 228th ACS National Meeting, Philadelphia, PA, August 22-26, 2004.  

Effect of Surfactant and Phospholipid Vesicles on Diazeniumdiolate Reactivity. Stacy E. Price, David L. Beyer, J. H. Wynne and K. M. Davies. Division of Medicinal Chemistry, 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003.  

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.  Waterhouse, David J.; Saavedra, Joseph E.; Wang, Lai Y.; Buzard, Gregory S.; Diwan, Bhalchandra A.; Singh, Shivendra V.; Davies, Keith M.; Citro, Michael L.; Ji, Xinhua; Shami, Paul J.; Keefer, Larry K..  225th ACS National Meeting, New Orleans, LA,  March 23-27, 2003.  

Effect of Hydrophobic Structure on Micellar Binding and Reactivity of Diazeniumdiolates. Dilara Jappar, Keith M. Davies and Stacy E. Price. 35th ACS Middle Atlantic Regional Meeting, Fairfax, VA, May 28-30, 2002.  

Binding and Reactivity of Diazeniumdiolates in Organized Surfactant Media.  Stacy E. Price, Dilara Jappar and  Keith M. Davies. 223rd ACS National Meeting, Orlando, FL, April 7-11, 2002.    

Micellar Binding and Catalysis of Nitric Oxide Dissociation from Diazeniumdiolates, Keith M. Davies, Stacy E. Price, Anne B. Cook, Patricia Lorenzo, Joseph E. Saavedra and Joseph A. Hrabie. 222nd ACS National Meeting, Chicago, August 2001  

Micellar Catalysis of Nitric Oxide Dissociation from Zwitterionic Diazeniumdiolates, Stacy E. Price, Patricia Lorenzo and Keith M. Davies. 79th Annual meeting of Virginia Academy of Science, James Madison University, Harrisonburg, VA, May 2001 

Synthesis of tris(methanol)hexa-μ-acetato-μ-3-oxo-triruthenium(II) acetate: Christopher T. Lloyd, James H. Wynne, George W. Mushrush and Keith M. Davies. An Undergraduate Laboratory Experiment.  221st ACS National Meeting, San Diego, CA; CHED 698; April 1, 2001

Kinetics and Mechanisms of Nitric Oxide Dissociation from Diazeniumdiolates, Keith M. Davies, David, A. Wink, Joseph E. Saavedra, Larry K. Keefer. 220th ACS National Meeting, Washington D.C. August 2000  

Micellar Catalysis of Nitric Oxide Dissociation from Diazeniumdiolates, Anne B. Cook, Keith M. Davies, Joseph E. Saavedra, Joseph A. Hrabie. 220th ACS National Meeting, Washington D.C. August 2000  

Diazeniumdiolates: Interrelationships with more traditional N-nitroso compounds, Keefer, Larry K.; Srinivasan, Aloka; Saavedra, Joseph E.; Hrabie, Joseph A.; Toscano, John P.; Davies, Keith M. 217th ACS National Meeting, Anaheim, Calif., March 21-25, 1999   

Electrochemical Investigation of SDS Microemulsion Solubilization and Electron Transfer for Ferrocene and Cobalt Derivatives, Keith M. Davies, Abul Hussam and Dilip Shah, 208th ACS National Meeting, Washington D.C., August, 1994

Redox Behavior of Lipophilic Cobalt Complexes, Invited seminar, Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, Md., August, 1993

Redox Behavior of Cobalt(III) Phenanthroline and Dipicolinate Complexes in Micellar Solutions: Correlation of Rate and Electrochemical Parameters. Keith M. Davies, Abul Hussam, Ritu Kansal and Peter King, Joint Southeastern-Middle Atlantic Regional ACS Meeting, Alexandria, Virginia, December, 1992

Redox Behavior of Cobalt Phenanthroline and Terpyridine Complexes in Micellar Solutions. Keith M. Davies and Abul Hussam, 204th ACS National Meeting, Washington D.C., August, 1992. 

Micellar Effects on Electrochemistry of Hydrophobic Metal Complexes. Keith M. Davies and Peter King, Virginia Academy of Science, Richmond, Virginia, May, 1992.  

Kinetic and Electrochemical Investigation of Electron Transfer Involving Substituted 1,10-Phenanthroline Cobalt(III) Complexes in Micellar Solutions of Sodium Dodecylsulfate. Keith M. Davies and Bayne R. Rector, 25th A.C.S. Middle Atlantic Regional Meeting, Newark, Delaware, May, 1991

Solvent and Electrolyte Effects in Electron Transfer Reactions of Bis(pyridyl)-dithiaether Copper(II) Complexes, Keith M. Davies, Kendall. D. Whyte and Arthur H. Gilbert, 200th A.C.S. National Meeting, Washington, D.C., August, 1990

Solvent and Electrolyte Effects in Electron Transfer Reactions of 1,8-Bis(2-pyridyl)-3,6-dithiaoctane: Specific Rate Enhancement by Tetrafluoroborate Ion. Keith M. Davies and Kendall D. Whyte, Virginia Academy of Science, Fairfax, Virginia, May, 1990.  

 Effect of Solvent on Cu(I)-Cu(II) Redox Reactivity, Invited Seminar, Chemistry Department, Georgetown University, Washington, D.C., September, 1990. 

Solvent and Electrolyte Studies on Electron‑Transfer Reactions of Bis(pyridyl)‑Dithiaether Copper(II), Keith M. Davies, Arthur H. Gilbert and Kendall D. Whyte, Southeastern Regional Meeting of American Chemical Society, Atlanta, Georgia, November, 1988

Effect of Ligand Structure on Copper(II)‑Copper(I) Redox Reactivity.  Keith M. Davies, Brien Byers and Bardia Guilani, Southeastern Regional Meeting of American Chemical Society, Louisville, Kentucky, November 1986. 

Ligand Constraints and Cu(II)‑Cu(I) Electron Transfer, Invited Seminar, Chemistry Department, Howard University, Washington, D.C., November 1986. 

Electron Transfer Reactions of Ruthenium Ammine Complexes with Copper(II) and Ruthenium(III) Complexes containing Thiaether Ligands.  Keith M. Davies, International Conference on the Chemistry of the Platinum Group Metals, Edinburgh, Scotland, July, 1984

Electron Transfer Reactions of Sterically Constrained Copper(II) Complexes with Ruthenium(II) Ammine Reductants.  Keith M. Davies, Southeastern Regional Meeting of the American Chemical Society, Raleigh, North Carolina, October 1984

Electron‑Transfer Reactions of Copper(I) and Copper(II) Complexes with Ammine Complexes of Ruthenium(III) and Ruthenium(II), Keith M. Davies, Southeastern Regional Meeting of ACS, Birmingham, Alabama, November, 1982

A Linear Free Energy Relationship for Outer‑Sphere Reduction of Ru(III) Ammine Complexes by Ti(III), Keith M. Davies and Joseph E. Earley, 12th ACS Middle‑Atlantic Regional Meeting, Hunt Valley, Md., April, 1978

Kinetics of Electron‑Transfer Between Titanium(III) and Ruthenium(III) Ammine Complexes, Keith M. Davies and Joseph E. Earley, 173rd ACS National Meeting, New Orleans, La. March, 1977. 

Thiocyanate Ion as a Bridging Ligand for Electron‑Transfer between Ruthenium(III) and Titanium(III), Joseph E. Earley, Ruth A. Lee and Keith M. Davies, XIX International Coordination Conference, Prague, Czechoslovakia, 1978

Factors Affecting Electron Transfer Between O2 and O22‑ Bridging Ligands in Binuclear Complexes of Cobalt(III), Keith M. Davies and A. Geoffrey Sykes, International Conference on Mechanisms of Reactions in Solution, Canterbury, England, July, 1970

Electron‑Transfer Reactions of Vanadium(II) and some Monosubstituted Pentacyanocobaltate(III) Ions, Keith M. Davies and James H. Espenson, Mid‑Western Regional Meeting of ACS, Manhattan, Kansas, November, 1968.

 

Recent Research Presentations by GMU Undergraduate Students

Reactivity of thiolate, hydroxide, and phenolate ions toward O2-arylated diazeniumdiolate prodrugs. Matthew S. Ning, Ramtin Ghods, Jackie Ta and  Keith M. Davies, Fall-2009 ACS National Meeting, Washington D.C., August 13, 2009.

Thiol activation of O2-arylated diazeniumdiolate prodrugs. Jackie Ta and Keith M. Davies, 7th Annual Undergraduate Research Conference, Georgetown University, April 3, 2009.

Diazeniumdiolate prodrug activation in model membrane systems. Keith M. Davies, Bach T. Dinh and Kevin, J. Dove, 232nd ACS National Meeting, INORG 138, San Francisco, CA, September 10, 2006.

Effect of model membrane systems on nitric oxide dissociation from diazeniumdiolate ions. Keith M. Davies, Bach T. Dinh, Kevin, J. Dove and Mazen El-Hajj,  230th  ACS National Meeting, BIOL 96, Washington D.C., Aug 30th, 2005.

Diazeniumdiolate Reactivity in Anionic Liposome Media. Mazen El-Hajj, Bach Dinh and Keith M. Davies. Colonial Academic Alliance Undergraduate Research Conference, Hofstra, N.Y., April 8-9, 2005. 

Liposome Transport and Reactivity of Diazeniumdiolates, Bach Dinh and Kevin Dove, Virginia Academy of Science, Undergraduate Research Symposium, Richmond, Virginia, October 2004.  

Diazeniumdiolate Reactivity in Liposome Media. Kevin J. Dove, Marit Barnett and Keith M. Davies. Division of Chemical Education. 228th ACS National Meeting, Philadelphia, PA, August 22-26, 2004.

Effect of Surfactant and Phospholipid Vesicles on Diazeniumdiolate Reactivity. Stacy E. Price, David L. Byer, James. H. Wynne and Keith. M. Davies. Division of Medicinal Chemistry, 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003.

Effect of Hydrophobic Structure on Micellar Binding and Reactivity of Diazeniumdiolates. Dilara Jappar, Keith M. Davies and Stacy E. Price. 35th ACS Middle Atlantic Regional Meeting, Fairfax, VA, May 28-30, 2002.

Binding and Reactivity of Diazeniumdiolates in Organized Surfactant Media.  Stacy E. Price, Dilara Jappar and  Keith M. Davies. Division of Chemical Education. 223rd ACS National Meeting, Orlando, FL, April 7-11, 2002.

Micellar Catalysis of Nitric Oxide Dissociation from Zwitterionic Diazeniumdiolates. Stacy E. Price, Patricia Lorenzo and Keith M. Davies. 79th Annual meeting of Virginia Academy of Science, James Madison University, Harrisonburg, VA, May 2001.

Micellar Binding and Catalysis of Nitric Oxide Dissociation from Diazeniumdiolates, Keith M. Davies, Stacy E. Price, Anne B. Cook, Patricia Lorenzo, Joseph E. Saavedra and Joseph A. Hrabie. Division of Colloid and Surface Chemistry. 222nd ACS National Meeting, Chicago, August 2001.

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RECENT STUDENT OUTCOMES

Bach Dinh, B.S. in Chemistry, George Mason University (2005); M.S. George Mason University, 2006. Patent Examiner, U.S. Patent and Trademark Office, Alexandria, Virginia.

Marit Barnett, B.A. in Chemistry, George Mason University (2004).  M.D. Uniformed Services University, Bethesda, Maryland.

David Byer, B.S. in Biology, George Mason University (2003). M.D.  Georgetown University, Washington, D.C.

Stacy E. Price, B.S. in Chemistry, George Mason University (2002); M.S. in Chemistry, George Mason University  (2003).  J.D. George Washington University School of Law, Washington, D.C.

Dilara Jappar, B.S. in Chemistry, George Mason University ( 2002).   Ph.D., Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan.