Chemistry 315          Organic Chemistry Lab I                        Summer 2019

This syllabus can be found at http://mason.gmu.edu/~sslayden/Lab/index.html

Important additional course information is found on the CHEM 315 section of BlackBoard.

Lab Text: J. R. Mohrig, D. G. Alberg, G. E. Hofmeister, P. F. Schatz, and C. N. Hammond, Laboratory Techniques in Organic Chemistry, 4th edition (2014).

Lab Manual: S. W. Slayden, R. J. Roth, and W. M. Stalick, Laboratory Manual: Organic Chemistry 315, 318 (2017).

Lecture Text: T. W. G. Solomons, C. B. Fryhle, and S. A. Snyder, Organic Chemistry, 12th edition (2016).

Videos: Most viewing assignments can be found at
https://ocw.mit.edu/resources/res-5-0001-digital-lab-techniques-manual-spring-2007/videos
(MIT OpenCourseWare Creative Commons license).

CHEM 313 lecture is a pre- or co-requisite for CHEM 315 lab. If you previously took CHEM 313, you must have earned at least a C to use it as a pre-requisite for Chem 315. If you drop or withdraw from CHEM 313, you must also drop/withdraw from CHEM 315.

Add, drop, and selective withdrawal deadlines can be found at http://registrar.gmu.edu.

It is the responsibility of all students to be familiar with and adhere to the GMU Honor Code.

If you are a student with a disability and you need academic accommodations, please contact Disability Services at 993-2474, http://ds.gmu.edu. All academic accommodations must be arranged through Disability Services.


Course Schedule

Lab Date

Experiment Title

Reading/Viewing Assignment

Report Due

Lab 1

May 20

Introduction and safety; check-in; citing information for the laboratory

Lab Manual pp 1-20

Mohrig ch 1 (omit 1.6, 1.7)

 

Lab 2

May 22

Melting point

Lab Manual pp 23-25

Mohrig ch 3.1, 3.3; 14

M Pt video

 

Lab 3

May 24

Recrystallization

Lab Manual pp 27-31

Mohrig ch 15 (221-230, 234-235); ch 9 (pp 132, 137-138, 140-142)

Recrystallization video (0-14:38 min)

Melting Point

Lab 4

May 29

Thin layer chromatography (TLC);
Recrystallization, cont'd.

Lab Manual pp 33-38

Mohrig pp 127-131, 253-254; ch 18

TLC video

 

Lab 5

May 31

I. Gas chromatography: alkyl acetates mixture

 

 

II. Refractive index

I. Lab Manual pp 39-43

Mohrig ch 20 (except 20.8 - see Manual explanation)

GC video 1; GC video 2

II. Lab Manual pp 45-47

Mohrig ch 13

Recrystallization

Lab 6

June 3

Infrared and ultraviolet-visible spectroscopy; mass spectrometry

Lab Manual pp 49, 53-56

Mohrig ch 21 (21.1-21.2, 21.7-21.9); ch 25 (pp 465-470); ch 24

TLC

Lab 7

June 5

Identification of an unknown; simple distillation to determine boiling point; IR continued

Lab Manual pp 49-51

Mohrig ch 12 (pp 173-174, 176-183); ch 21 (21.3-21.5, 21.10-21.11)

Distillation video (0-8:41 min); IR sample prep video

GC Acetates

Lab 8

June 7

Fractional distillation

Lab Manual pp 59-63 [Disregard sections pertaining to Simple Distillation.]

Mohrig ch 12 (12.4, 12.8)

Distillation video (8:41-11:22 min)

Identification of Unknown

Lab 9

June 10

Isolation of caffeine

Lab Manual pp 67-70

Mohrig ch 10 (10.1 [except pp. 144-146], 10.3-10.5, 10.7); ch 11 (11.1-11.3); p. 321 (IR cast film)

Extraction video (0-11:25, 14:30-16:40 min)

Fractional distillation

Lab 10

June 12

Gas chromatography: analysis of distillate

Lab Manual pp 65-66

Mohrig ch 20

Isolation of caffeine

Lab 11

June 14

Qualitative organic analysis: alkanes, alkenes, alkynes, aromatics, alkyl & aryl halides, alcohols

Lab Manual pp 75-88

GC of distillate

Lab 12

June 17

Qualitative organic analysis continued

 

Lab 13

June 19

Synthesis of tert-pentyl chloride

Lab Manual pp 71-73

Mohrig ch 3.2; ch 10.2

Qualitative analysis

Lab 14

June 21

Final exam (Location TBD)

 

Synthesis of tert-pentyl chloride