Chemistry 318     Organic Chemistry Lab II     Fall 2018
This syllabus can be found at http://mason.gmu.edu/~sslayden/Lab/index.html

Lab Text: J. R. Mohrig, D. G. Alberg, G. E. Hofmeister, P. F. Schatz, and C. N. Hammond, Laboratory Techniques in Organic Chemistry, 4th edition (2014).

Lab Manual: S. W. Slayden, R. J. Roth, and W. M. Stalick, Laboratory Manual: Organic Chemistry 315, 318 (2017).

Lecture Text: T. W. G. Solomons, C. B. Fryhle, and S. A. Snyder, Organic Chemistry, 12th edition (2016).  

Videos: Most viewing assignments can be found at
https://ocw.mit.edu/resources/res-5-0001-digital-lab-techniques-manual-spring-2007/videos
(MIT OpenCourseWare Creative Commons license).

CHEM 314 lecture is a pre- or co-requisite for CHEM 318 lab. If you previously took CHEM 314, you must have earned at least a C to use it as a pre-requisite for Chem 318. If you drop or withdraw from CHEM 314, you must also drop/withdraw from CHEM 318.  

Add, drop, and selective withdrawal deadlines can be found at http://registrar.gmu.edu.

Policies for Chem 318 (grading, safety, notebook format, etc.) appear in the Lab Manual on pages 1-20. These will be supplemented by your lab instructor.  

It is the responsibility of all students to be familiar with and adhere to the GMU Honor Code.


Date

Experiment Title

Reading Assignment

Aug 27-31

Introduction and safety; check-in; NMR video

Lab Manual 1-20

Sep 3

Labor Day - No classes

 

Sep 4-10

Nuclear magnetic resonance spectroscopy (1H- and 13C-NMR); spectroscopy problem set

Lab Manual 91

Mohrig ch 22 (except 22.1-22.3, 22.8, 22.10, pp. 382-391); 23.1-23.2

Sep 11-17

Bromination of toluene; review IR; NMR continued.

pdf: http://mason.gmu.edu/~sslayden/Lab/318/spectra-prob-set-318-current.pdf

doc:http://mason.gmu.edu/~sslayden/Lab/318/spectra-prob-set-318-current.doc

Lab Manual 93-100, 49-58

Mohrig 22.11, 21.1-21.5, 21.7-21.11

Solomons Sec. 15.1-15.3

IR sample prep video

Sep 18-24

Nitration of methyl benzoate

Lab Manual 103-106

Mohrig 3.2, 15.2, 15.3, 15.5, 15.8, 9.4, 9.6

Solomons Sec. 15.8-15.9

Recrystallization video (9:51-14:33 min)

Sep 25-Oct 1

Synthesis of 4,4'-di-tert-butylbiphenyl; nitration of methyl benzoate continued

Lab Manual 107-111

Mohrig 7.1, 10.3-10.5, 10.7, 11.1-11.3

Solomons 15.6A, C

MPt video; Reflux video (0-4:30 min)

Oct 2-9

[Mon. lab meets on Tue.]

Identification of an unknown, part 1

Lab Manual 113-114; 45-47; 49-51

Mohrig [12.3-12.3a, 12.8], [13.3-13.4]

Distillation video (0-8:41 min)

Oct 10-16

Identification of an unknown, part 2; GMU NMR Center (PH 18)

Mohrig 22.1, 22.2 (pp. 353-355)

NMR document

Oct 17-23

Grignard reaction -Synthesis of benzoic acid, part 1

Experimental Procedure (not in Manual)

Solomons 12.6B, 12.7B, 12.8B, 17.3(6.)


Oct 24-30

Isolation and recrystallization of benzoic acid, part 2

Experimental Procedure (not in Manual)
Mohrig 10.2

Extraction video (0-11:25, 14:30-16:40 min)

Oct 31-Nov 6

Qualitative & spectroscopic analysis of aldehydes and ketones

Lab Manual 119-125

Solomons 16.11, 16.13, 16.14

Nov 7-13

Synthesis of banana oil

Lab Manual 127-130

Mohrig 7.1, 10.3-10.5, 10.7, 11.1-11.3

Solomons 17.7A

Nov 14-20

Synthesis of dibenzalacetone

Lab Manual 131-132

TLC of dibenzalacetone

Mohrig 18.6, 18.8, 18.9, 15.2, 15.3, 15.5, 15.8, 9.4, 9.6

Nov 21-23

Thanksgiving recess - No classes

 

Nov 26-30

Synthesis of biodiesel

Lab Manual 133-137

Mohrig pp. 74-75

Dec 3-7

Final exam

If you are a student with a disability and you need academic accommodations, please contact Disability Services at 993-2474, http://ds.gmu.edu. All academic accommodations must be arranged through Disability Services.