FISH OIL SUPPLEMENTS FOR MANIC DEPRESSION

Scientists believe they have found a surprising new ally in their efforts to understand and treat the sharp mood swings of manic depression--the fatty acids of fish oil.

Fish oil is especially high in omega-3 fatty acids, a family of long-chained polyunsaturated fats that have been associated with reduced cardiovascular disease and other health benefits.

The body's highest concentrations of omega-3 fatty acids are in the eyes and the brain, where neurobiologists believe they are essential to the proper functioning of cell membranes. If levels of omega-3 fatty acids are too low, they have theorized, then essential chemical pathways become overwhelmed and mental disorders can occur.

In the study, the patients were given 10 grams of fish oil fatty acids a day, an extremely high dose. The capsules contained eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the two primary molecules of the omega-3 family. There were only minor side effects--some gastric trouble and diarrhea--which were easily controlled. In the Harvard study, all the patients continued on their other medications. About half were also treated with fish oil capsules, while the others got olive oil as a placebo.

While fish oil has long been used as a safe dietary supplement, doctors warn that it can oxidize if not properly stored. Experts in the field advise not taking fish oil capsules if they have more than a slightly fishy smell. If a patient takes large doses of fish oil, doctors generally recommend taking vitamin E or C as an antioxidant as well.

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The above is a condensation of the complete Washington Post article relating to the treatment of manic depression with the fatty acids of fish oil. "Fish Oil May Aid Against Manic Depression: Study Attributes Dramatic Improvement in Patients to Omega-3 Fatty Acids in Supplements", By Marc Kaufman Washington Post Staff Writer Tuesday, April 27, 1999; Page Z07